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An in-house radioimmuno assay for serum thyroglobulin was developed in our laboratory and compared its relative sensitivity with that of whole body scan in the detection of residual tumour or metastases and evaluated the predictive value of serum thyroglobulin in the clinical course of the disease. Ninety six patients after thyroidectomy were followed up for a maximum period of five years in this study. The sensitivity and specificity of serum thyroglobulin were found to be close to that of whole body scan (85% and 94% respectively). According to this study, a serum thyroglobulin >40 ng/ml can differentiate between patients with metastases and those in remission. Serum thyroglobulin can replace whole body scan during the subsequent follow-up if the patient had concordant whole body scan and serum thyroglobulin during initial assessment.  相似文献   
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The scrambling complexity hypothesis based on working memory or locality accounts as well as syntactic accounts have proposed that processing a scrambled structure is difficult. However, the locus of this difficulty in sentence processing remains debatable. Several studies on multiple languages have explored the effect of scrambling on sentence processing and not all languages have shown an advantage for the canonical word order. Using a self-paced reading paradigm, we studied the effect of scrambling on semantic anomaly detection in Hindi sentence comprehension employing three word order types. Reading times on critical verbs, judgment latency, and error rates showed significant effect of word order type. The results further revealed significant interactions between word order and anomaly type. The patterns of results suggest that the canonical word order does not necessarily have a processing advantage in terms of speed and accuracy over non-canonical orders and do not provide support to sentence processing accounts that assume an advantage for canonical structures. The results indicate that processing speed depends on the distance between the subject and the verb, thus supporting a locality dependent working memory based model of sentence processing. The results provide evidence for the role of specific cognitive processes in Hindi sentence processing with further implications for language and literacy acquisition in Hindi.  相似文献   
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The history of Early Childhood Education in India dates from the 1890s, though growth remained restricted till Independence. In 1953, the Government first began to play a larger role, promoting, through voluntary effort, kindergartens in rural areas. The first major training programme was the Bal Sevika (Child care worker) Training scheme in 1961 by the Indian Council of Child Welfare.

The second big breakthrough came with the Integrated Child Development Services in 1974, the world's largest to attempt to provide a package of services to the most vulnerable children. The attached four-month job training, intended to develop paraprofessionals with multiple roles, supported by untrained ‘helpers’ is hence somewhat diluted in content.

In addition several other limited kinds of training in Early Childhood Education are available.

Training programmes have had to face several recurrent constraints related to issues of both quantity and quality—availability at different levels; relevance of content and appropriateness of methodology; motivation; certification; and the development of a trainer cadre.

Recently, innovative training programmes, three of which are mentioned, are attempting to meet these challenges in new ways.  相似文献   

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This study investigated the development of turn and turn measurement concepts within a computer-based instructional unit. We collected data within two contexts, a pilot test of this unit with four third graders and a field test in two third grade classrooms. We conducted paper-and-pencil assessments, interviews, and interpretive case studies. Turns were less salient for children than forward and back motions. Students evinced a progressive construction of imagery and concepts related to turns. They gained experience with physical rotations, especially rotations of their own bodies. In parallel, they gained limited knowledge of assigning numbers to certain turns, initially by establishing benchmarks. A synthesis of these two domains — turn-as-body-motion and turn-as-numbe — constituted a critical juncture in learning about turns for some students. Some common misconceptions, such as conceptualizing angle measure as a linear distance between two rays, were not in evidence. This supports the efficacy and usefulness of instructional activities such as those employed.  相似文献   
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